Resumo do Componente Curricular

Dados Gerais do Componente Curricular

Tipo do Componente Curricular:	MÓDULO
Unidade Responsável:	PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS (13.07)
Código:	PPGCF0007
Nome:	CHANNELS, CARRIERS & PUMPS IN CARDIOVASCULAR HEALTH AND DISEASES
Carga Horária Teórica:	15 h.
Carga Horária Prática:	0 h.
Carga Horária de Ead:	0 h.
Carga Horária Total:	15 h.
Pré-Requisitos:
Co-Requisitos:
Equivalências:
Excluir da Avaliação Institucional:	Não
Matriculável On-Line:	Sim
Horário Flexível da Turma:	Não
Horário Flexível do Docente:	Sim
Obrigatoriedade de Nota Final:	Sim
Pode Criar Turma Sem Solicitação:	Não
Necessita de Orientador:	Não
Exige Horário:	Sim
Permite CH Compartilhada:	Não
Permite Múltiplas Aprovações:	Não
Quantidade de Avaliações:	1
Ementa/Descrição:	Transport systems across cell membranes: a) Structural basis b) Regulation and Integration c) Current Topics: sexual dimorphism and aging 2) Ion Channels a) Overview b) Ion channels as therapeutic targets in cardiovascular disease c) Channelopathies d) New therapeutic modalities for ion channels 3) Trans porters a) Overview b) Emerging opportunities as therapeutic targets 4) Ion - motive ATPases a) Overview b) Ion - motive ATPases as therapeutic targets in cardiovascular disease
Referências:	BIBLIOGRAFI A BÁSICA 1. Belliard A, Gulati GK, Duan Q, Alves R, Brewer S, Madan N, Sottejeau Y, Wang X, Kalisz J, Pierre SV. Ischemia/reperfusion - induced alterations of enzymatic and signaling functions of the rat cardiac Na+/K+ - ATPase: protection by ouabain precondi tioning. Physiological reports. 2016; 4(19). 2. Madan N, Xu Y, Duan Q, Banerjee M, Larre I, Pierre SV, Xie Z. Src - independent ERK signaling through the rat α 3 isoform of Na/K - ATPase. American journal of physiology. Cell physiology. 2017; 312:C222 - C232. 3. Feng X, Turley J, Xie Z, Pierre SV, Koc H, Khan MO, Hao J. An LC - MS/MS method for the determination of digitoxigenin in skin samples and its application to skin permeation and metabolic stability studies. Journal of pharmaceutical and biomedical analysis. 2017; 138:378 - 385. 4. Yu H, Cui X, Zhang J, Xie JX, Banerjee M, Pierre SV, Xie Z. Heterogeneity of signal transduction by Na - K - ATPase α - isoforms: role of Src interaction. American journal of physiology. Cell physiology. 2018; 314(2):C202 - C210. 5. Duan Q, Xu Y, Marck PV, Kalisz J, Morgan EE, Pierre SV. Preconditioning and Postconditioning by Cardiac Glycosides in the Mouse Heart. Journal of cardiovascular pharmacology. 2018; 71(2):95 - 103. BIBLIOGRAFIA COMPLEMENTAR 1. Kutz LC, Mukherji ST, Wang X, Bryant A, Larre I, Heiny JA, Lingrel JB, Pierre SV, Xie Z. Isoform - specific role of Na/K - ATPase α 1 in skeletal muscle. American journal of physiology. Endocrinology and metabolism. 2018; 314(6):E620 - E629. 2. Marck PV, Pierre SV. Na/K - ATPase Signaling and Cardiac Pre/Postconditioning with Cardiotonic Steroids. International journal of molecular sciences. 2018; 19(8). 3. Buzaglo N, Golomb M, Rosen H, Beeri R, Ami HC, Langane F, Pierre S, Lichtstein D. Augmentation of Ouabain - Induced Increase in Heart Muscle Contract ility by Akt Inhibitor MK - 2206. Journal of cardiovascular pharmacology and therapeutics. 2019; 24(1):78 - 89. 4. Xie J, Ye Q, Cui X, Madan N, Yi Q, Pierre SV, Xie Z. Expression of rat Na - K - ATPase α 2 enables ion pumping but not ouabain - induced signaling in α 1 - deficient porcine renal epithelial cells. American journal of physiology. Cell physiology. 2015; 309(6):C373 - 82.

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